From Perugia:
Follow the E45 towards Todi - Exit at »Todi - San Damiano«. When you reach the roundabout on the outskirts of Todi, take the second exit towards Collevalenza. After approximately 7 km, you will find signs for Relais Todini on the right.

From Terni:
Follow the E45 towards Perugia - Exit at Collevalenza. When you reach the small town of Collevalenza, turn left towards Todi. After approximately 1km, you will see signs for Relais Todini on your left.